Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Transient electrocardiographic abnormalities during hypoglycemia. Sex and bmi alter the benefits and risks of sulfonylureas and. Insulin secretagogues must be avoided, especially longacting sulfonylureas. Doseresponse relation between sulfonylurea drugs and. Por 28allele0, may explain interindividual variation in.
The use of octreotide appears to reduce the number of hypoglycemic episodes and glucose requirements, with no reported toxicities associated with its use for sulfonylureainduced hypoglycemia following overdose. Pdf octreotide for sulfonylureainduced hypoglycemia. A framework for evaluating stratification using routine clinical and individual trial data. Since it came onto the market in 1983, glyburide has been one of the most popular sulfonylureas. The mean sd time to onset of hypoglycemia in children not given any prophylactic treatment was 2. The aim of this study was to assess i the effect of por 28 allele on sulfonylurea induced hypoglycemia risk and ii the association of cyp2c92 allele with. If the patient does not present obesity, idpp4, isglt2 or gliclazide, sulfonylurea.
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